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Urolithin A Improves the Gut Barrier

It is well documented that the gut microbiome plays an essential role in human health. Urolithin A is a postbiotic derived from the microbe metabolism of polyphenols in pomegranates and berries. This study demonstrated that Urolithin A had a positive effect on reducing inflammation and improving the gut barrier.

October 30, 2022

Key takeaways

Imbalances in the gut microbiome are associated with a number of health conditions, including inflammatory bowel disease, neurological disorders, obesity, and diabetes.

The microbes in our gut produce important metabolites that confer health onto the human host. Urolithin A is one of these metabolites.

Urolithin A exhibited a robust protective effect on the gut barrier by up regulating tight junctions and promoting anti-inflammatory activities.

Urolithin A was able to mitigate colitis in pre-clinical disease models.

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Rajbir Singh, Sandeep Chandrashekharappa, Sobha R. Bodduluri, Becca V. Baby, Bindu Hegde, Niranjan G. Kotla, Ankita A. Hiwale, Taslimarif Saiyed, Paresh Patel, Matam Vijay-Kumar, Morgan G. I. Langille, Gavin M. Douglas, Xi Cheng, Eric C. Rouchka, Sabine J. Waigel, Gerald W. Dryden, Houda Alatassi, Huang-Ge Zhang, Bodduluri Haribabu, Praveen K. Vemula, Venkatakrishna R. Jala

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