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Urolithin A Improves Insulin Sensitivity

This study evaluated the role of Urolithin A, a metabolite from ellagic acid in food, in improving insulin sensitivity. Mice were given either Urolithin A or another compound called dimethyl sulfoxide and fed a high-fat diet for 12 weeks. Results showed the mice given Urolithin A had improved insulin sensitivity, highlighting the benefits in consuming ellagic-acid rich foods and supplements containing Urolithin A.

October 31, 2022

Key takeaways

Insulin resistance is prevalent around the world, affecting 15.5 to 46.5% of the population.

Urolithin A is a gut metabolite (i.e., a byproduct of digestion) of ellagic acid-containing foods that plays a role in energy metabolism and insulin sensitivity.

Study results show how Urolithin A plays a direct role in improving insulin sensitivity, even when eating a high-fat, pro-inflammatory diet.

Read paper


Ashley Mulcahy Toney, Rong Fan, Yibo Xian, Virginia Chaidez, Amanda E Ramer-Tait, Soonkyu Chung

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