October 31, 2022
Key takeaways
This study showed that treatment with Amazentis’ proprietary Urolithin A supplement, Mitopure, significantly improved the cancer-fighting properties of T-cells, a key part of the immune system.
Urolithin A renewed the energy factories of the T-cells via a cellular recycling pathway called mitophagy and so helped maintain their anti-cancer activity for longer.
Mice with colorectal tumors that were fed Urolithin A saw significantly reduced cancer growth, because of stronger T-cell antitumor properties.
A similar effect was seen in human cells. Human T-cells cultured with Urolithin A produced more T memory stem cells, potentially giving the immune cells more cancer-killing power.
Authors
Dominic Denk, Valentina Petrocelli, Claire Conche, Moritz Drachsler, Paul K. Ziegler, Angela Braun, Alena Kress, Adele M. Nicolas, Kathleen Mohs, Christoph Becker, Markus F. Neurath, Henner F. Farin, Christian J. Buchholz, Pénélope A. Andreux, Chris Rinsch, Florian R. Greten