Mitochondrial dysfunction is a hallmark of the aging process and it is closely associated with the decline in skeletal muscle that occurs with aging. Activating mitophagy is an opportunity to slow age-related muscle decline. This study aimed to investigate the effects of Urolithin A on muscle health in older adults aged 40-64. The study found that daily intake of Urolithin A significantly improved muscle health and endurance after four months of treatment.
October 28, 2022
Impaired mitochondrial function is associated with age-related decline in skeletal muscle health. Targeting mitophagy represents a novel approach to improving muscle health in older adults.
The goal of this trial was to evaluate the health benefits of 500 mg and 1000 mg doses of Urolithin A in healthy, overweight individuals aged 40-64 over the course of four months. Participants had an average BMI of 29.
Oral supplementation with Urolithin A at both doses significantly increased muscle strength in the leg. 1000 mg doses of Urolithin A positively impact exercise-performance measures such as V02 max and a six-minute walk test.
Muscle biopsies demonstrated activation of mitophagy in muscle cells, and plasma markers demonstrated improvements in mitochondrial health and inflammation in the Urolithin A treated groups.
Daily supplementation at doses of 500 mg and 1000 mg is safe and well tolerated, and resulted in increased levels of circulating Urolithin A.
Anurag Singh, Davide D’Amico, Pénélope A. Andreux, Andréane M. Fouassier, William Blanco-Bose, Mal Evans, Patrick Aebischer, Johan Auwerx, Chris Rinsch