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Urolithin A Improves Muscular Health in Middle-Aged Adults

Mitochondrial dysfunction is a hallmark of the aging process and it is closely associated with the decline in skeletal muscle that occurs with aging. Activating mitophagy is an opportunity to slow age-related muscle decline. This study aimed to investigate the effects of Urolithin A on muscle health in older adults aged 40-64. The study found that daily intake of Urolithin A significantly improved muscle health and endurance after four months of treatment.

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October 28, 2022

Key takeaways

Impaired mitochondrial function is associated with age-related decline in skeletal muscle health. Targeting mitophagy represents a novel approach to improving muscle health in older adults.

The goal of this trial was to evaluate the health benefits of 500 mg and 1000 mg doses of Urolithin A in healthy, overweight individuals aged 40-64 over the course of four months. Participants had an average BMI of 29.

Oral supplementation with Urolithin A at both doses significantly increased muscle strength in the leg. 1000 mg doses of Urolithin A positively impact exercise-performance measures such as V02 max and a six-minute walk test.

Muscle biopsies demonstrated activation of mitophagy in muscle cells, and plasma markers demonstrated improvements in mitochondrial health and inflammation in the Urolithin A treated groups.

Daily supplementation at doses of 500 mg and 1000 mg is safe and well tolerated, and resulted in increased levels of circulating Urolithin A.

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Anurag Singh, Davide D’Amico, Pénélope A. Andreux, Andréane M. Fouassier, William Blanco-Bose, Mal Evans, Patrick Aebischer, Johan Auwerx, Chris Rinsch

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